-synuclein, that is a primary element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) anxiety, recommend that dysfunction of the intracellular proteinase devices, for instance ubiquitin-proteasome method or lysosomal procedure, which eliminates unne

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